The drive from Mammoth Lakes to Lancaster is approximately 350 kilometers, taking you through the Eastern Sierra and into the Antelope Valley. You will follow US-395 South before merging onto CA-14 South. The trip takes about 4 hours. This route is a common path for those moving from the mountains to the high desert of Southern California.
Total Distance: 350 km driving distance; 300 km straight-line air distance.
The CA-14 highway can be windy; keep both hands on the wheel.
Spring for the California Poppy Reserve bloom in Lancaster.