The drive from Monona to St. Louis covers approximately 600 kilometers. You will primarily use I-90 East to Rockford, then transition to I-39 South and I-55 South. Expect a total travel time of about 6 hours and 30 minutes. This route takes you through the heart of Illinois, passing through Bloomington and Springfield. It is a straightforward interstate drive with many service options.
Total Distance: 600 km driving distance; 520 km straight-line air distance.
I-55 is a very direct route into downtown St. Louis.
Spring or Fall for comfortable temperatures for sightseeing.