Bus
Driving
Murfreesboro to Knoxville
Updated: 28 May 2026
The drive from Murfreesboro to Knoxville is a 250-kilometer journey along I-40 East. You will pass through Cookeville before reaching Knoxville. The drive takes approximately 2.5 hours. This route is a major east-west corridor. Bus services are available for those who prefer not to drive.
Total Distance: 250 km driving, 220 km air distance.
Fastest Way
Driving, taking 2.5 hours via I-40.
Cheapest Way
Bus, with tickets starting at $25.
Compare Murfreesboro to Knoxville Routes
|
Direct
|
Direct
|
|
|---|---|---|
| Duration | 4 hours | 2 hours 30 mins |
| Avg Price | $25-$60 | $30-$50 in fuel |
| Operator | Greyhound | Personal Vehicle |
| Route | Murfreesboro Bus Station to Knoxville Station. | I-40 East through Cookeville. |
| Tip | Book early for the best rates. | I-40 can be busy near Knoxville. |
Travel Tips
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TrafficI-40 can be busy near Knoxville.
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DiningTry the local food in Knoxville.
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NavigationUse GPS for city navigation.
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ParkingDowntown Knoxville has many garages.
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WeatherTennessee is humid; dress accordingly.
Safety Tips
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SpeedingWatch for speed changes in small towns.
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FatigueTake breaks in Cookeville.
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VisibilityUse lights in rain.
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EmergencyKeep a roadside kit.
People Also Ask
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Is there a train?No, there is no passenger rail service.
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How long is the drive?About 2.5 hours.
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Is I-40 toll-free?Yes, it is toll-free.
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Best time to visit?Autumn.
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Is it a safe route?Yes, it is a major interstate.
Quick Info
- From Murfreesboro, Tennessee, United States
- To Knoxville, Tennessee, United States
-
Modes
Best Time to Travel
Autumn for the beautiful foliage.
Things to Do in Knoxville
1
Market Square
Visit the historic square.
2
Knoxville Museum of Art
Explore the museum.
3
World's Fair Park
Enjoy the park.
4
Ijams Nature Center
Experience the nature center.
Tags
Murfreesboro to Knoxville
I-40 East
Knoxville travel
Murfreesboro to Knoxville bus
road trip Tennessee
Knoxville tourism
driving to Knoxville
Greyhound Murfreesboro
