Is there a train to Knoxville?

No, there is no passenger rail service to Knoxville.

What is the best route?

I-22 and I-75 is the most direct route.

No, there are no tolls on this route.

Yes, the roads are well-maintained.

New Albany

Knoxville

Driving

New Albany to Knoxville

Updated: 28 May 2026

The drive from New Albany to Knoxville is approximately 480 kilometers, primarily using I-22 and I-75. This route takes you through the scenic landscapes of North Mississippi, Alabama, and Tennessee. Expect a drive time of about 5 hours. This is a common route for those visiting the Great Smoky Mountains and the city of Knoxville. Driving is the only practical mode for this journey.

Total Distance: 480 km driving distance; 430 km straight-line air distance.

Fastest Way

Driving via I-22 and I-75 is the fastest and most direct route.

Cheapest Way

Driving is the most economical way to reach Knoxville.

Compare New Albany to Knoxville Routes

Driving

Direct

Duration

5 hours

Avg Price

$65-$80 in fuel

Operator

Personal Vehicle

Route

I-22 East to I-75 North to Knoxville.

The road is mostly four-lane; be patient with slower traffic.

Travel Tips

Traffic
Knoxville can be busy during rush hour.
Parking
Parking is readily available in the downtown area.
Dining
Try the local Southern cuisine in downtown Knoxville.
Weather
Be prepared for hot summers and mild winters.
Navigation
I-75 is well-marked, but use GPS for local streets.

Safety Tips

Driving
Be cautious of wildlife on rural roads at night.
Personal Safety
Knoxville is generally safe, but always be aware of your surroundings.
Vehicle
Ensure your car is in good condition for the drive.
Emergency
Keep a list of emergency contacts in your vehicle.