Driving
Natchez to Knoxville
Updated: 28 May 2026
The drive from Natchez to Knoxville covers 880 kilometers and takes approximately 9 hours. You will travel north through Mississippi and Alabama before merging onto I-75 North toward Knoxville. This route takes you through the heart of the Appalachian region. Knoxville is a gateway to the Great Smoky Mountains and offers a mix of history and outdoor adventure. It is a long-distance drive that requires careful planning.
Total Distance: 880 km driving distance; 750 km straight-line air distance.
Fastest Way
Driving via I-22 and I-75 is the fastest, taking 9 hours.
Cheapest Way
Driving is the most practical and cost-effective method.
Compare Natchez to Knoxville Routes
Driving
Direct
Duration
9 hours
Avg Price
$110-$130
Operator
Personal Vehicle
Route
US-61 to I-22 East, then I-75 North.
Plan for an overnight stop in Birmingham or Chattanooga.
Travel Tips
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Rest StopsChattanooga is a good place to stop for a long break.
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TrafficExpect heavy traffic in Knoxville during peak hours.
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WeatherMountain weather can be unpredictable; check forecasts.
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DiningKnoxville has a diverse food scene with many local options.
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NavigationI-75 is well-marked; follow signs for Knoxville.
Safety Tips
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FatigueThis is a very long drive; consider staying overnight.
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EmergencyKeep a roadside emergency kit in your car.
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VisibilityUse headlights in the mountains, especially during fog.
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SpeedingMaintain posted speeds, especially on mountain curves.
People Also Ask
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Is there a train?No, there is no passenger rail service to Knoxville.
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How long is the drive?The drive takes approximately 9 hours.
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Are there tolls?No, there are no tolls on this route.
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Is it a safe route?Yes, it is a standard interstate route.
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Can I fly?There are no direct flights from Natchez to Knoxville.
Quick Info
- From Natchez, Mississippi, United States
- To Knoxville, Tennessee, United States
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Modes
Best Time to Travel
Fall for the stunning autumn foliage in the mountains.
Things to Do in Knoxville
1
Market Square
Explore this historic downtown area filled with shops and restaurants.
2
Sunsphere
Visit this iconic structure built for the World's Fair.
3
Great Smoky Mountains National Park
Take a short drive from Knoxville to explore the most visited national park.
4
Ijams Nature Center
Enjoy hiking and outdoor activities in this urban nature park.
Tags
Natchez to Knoxville
I-75 route
Tennessee travel
Natchez to Knoxville distance
driving to Knoxville
Mississippi to Tennessee
travel guide
road trip
