Driving
North Charleston to Knoxville
Updated: 28 May 2026
The drive from North Charleston to Knoxville is a 350-mile journey northwest. You will take I-26 West to I-40 West. The drive typically takes about 5 hours and 30 minutes. You will cross from South Carolina into North Carolina and then Tennessee. Knoxville is a beautiful city near the Great Smoky Mountains.
Total Distance: 563 km driving distance; 480 km straight-line air distance.
Fastest Way
Driving via I-26 and I-40 is the fastest route, taking 5.5 hours.
Cheapest Way
Driving your own vehicle is the most cost-effective option.
Compare North Charleston to Knoxville Routes
Driving
Direct
Duration
5 hours 30 mins
Avg Price
$60-$80 in fuel
Operator
Personal Vehicle
Route
I-26 West to I-40 West
I-26 and I-40 are major highways; expect heavy traffic.
Travel Tips
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TrafficExpect heavy traffic in Knoxville.
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FuelGas is available along I-26 and I-40.
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Rest StopsUse rest areas on I-26 and I-40.
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NavigationUse a GPS to navigate Knoxville.
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PlanningKnoxville is a major tourist destination; book early.
Safety Tips
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SpeedingWatch your speed on I-26 and I-40.
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TrucksGive large trucks space.
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EmergencyKeep a roadside kit in your car.
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VisibilityUse headlights in rain.
People Also Ask
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Is there a train?No direct train service from North Charleston to Knoxville.
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How long is the drive?The drive is approximately 5 hours 30 minutes.
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Are there tolls?No, there are no toll roads on this route.
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Is it a scenic drive?Yes, it is a scenic mountain drive.
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Can I fly?There are no direct commercial flights between North Charleston and Knoxville.
Quick Info
- From North Charleston, South Carolina, United States
- To Knoxville, Tennessee, United States
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Modes
Best Time to Travel
Spring and Fall are the best times to visit.
Things to Do in Knoxville
1
Great Smoky Mountains National Park
A world-famous national park.
2
Market Square
A vibrant area with shops and restaurants.
3
Sunsphere
A historic tower with views.
4
Ijams Nature Center
A large nature preserve.
Tags
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