The drive from Oak Park to Louisville is approximately 400 miles, taking about 6 hours. You will travel south through Ohio, primarily using I-75 and I-71. Louisville is known for the Kentucky Derby, bourbon distilleries, and its vibrant riverfront. This is a manageable one-day drive.
Total Distance: 640 km driving distance; 550 km straight-line air distance.
Cincinnati is a great place to stop for lunch.
May for the Kentucky Derby festivities or September for pleasant weather.