The drive from Ocean Isle Beach to Columbia, South Carolina, covers approximately 185 miles. You will head inland via US-701 North toward Conway, then connect to SC-22 and eventually I-20 West. This route takes you through the rural landscapes of the Carolinas. The journey typically takes about 3 hours. Columbia is the state capital and home to the University of South Carolina.
Total Distance: 298 km driving distance; 255 km straight-line air distance.
Be prepared for rural roads with limited services between Ocean Isle Beach and I-20.
Visit in the spring or fall to enjoy the outdoor activities in Columbia's riverfront parks.