The journey from Ocean Isle Beach to Minneapolis is a long-haul trip of approximately 1,400 miles. You will travel north through the Appalachian region and then west across the Midwest. The route typically involves I-77 North to I-90 West. Expect a total driving time of 22 to 24 hours, requiring at least two overnight stops.
Total Distance: 2250 km driving, 1800 km air distance.
Plan for two overnight stops, perhaps in Columbus and Chicago.
Summer months to avoid the harsh winter conditions of the upper Midwest.