Is there a direct flight?

No, there are no direct commercial flights between Paducah and Knoxville.

How long is the drive?

The drive is approximately 350 miles and takes about 5.5 hours.

Is driving recommended?

Driving is the only practical way to travel between these two cities.

What is the best highway?

I-24 E to I-40 E is the most direct and efficient route.

There is no direct passenger rail service between Paducah and Knoxville.

Paducah

Knoxville

Driving

Paducah to Knoxville

Updated: 28 May 2026

The journey from Paducah to Knoxville is a 350-mile drive across Kentucky and Tennessee. The most direct route involves taking I-24 to I-40, passing through Nashville. This route offers a scenic drive through the heart of the South. Knoxville is the gateway to the Great Smoky Mountains and offers a vibrant downtown area. This is a straightforward road trip perfect for a weekend getaway.

Total Distance: 560 km driving; 480 km air distance.

Fastest Way

Driving is the only practical way to reach Knoxville in a single day.

Cheapest Way

Driving is the most cost-effective and practical method for this route.

Compare Paducah to Knoxville Routes

Driving

Direct

Duration

5 hours 30 mins

Avg Price

$60-$100 in fuel

Operator

Personal Vehicle

Route

I-24 E to I-40 E through Nashville.

Expect heavy traffic in Nashville; plan your trip to avoid peak hours.

Travel Tips

Traffic
Nashville traffic can be heavy; plan your travel times to avoid rush hour.
Weather
Knoxville weather can be unpredictable; pack layers.
Dining
Explore the local food scene, especially the Southern-style restaurants.
Parking
Downtown Knoxville has several parking garages; check for daily rates.
Booking
Book your hotel in advance, especially during University of Tennessee events.

Safety Tips

Road Conditions
Check for construction on I-40 before departing.
Vehicle Safety
Never leave anything in your car, as break-ins are common in tourist areas.
Emergency Services
Know the location of the nearest hospital or urgent care center.
Navigation
Use real-time traffic apps to navigate the city's freeway system.