The journey from Pensacola to Charleston covers approximately 750 kilometers. The most efficient route is via I-10 East to I-95 North. Expect a driving time of about 7.5 hours. This is a popular route for travelers heading to the historic coast of South Carolina. Driving is the most practical and common way to make this trip.
Total Distance: 750 km driving distance; 650 km straight-line air distance.
Traffic can be heavy near the Charleston metro area during rush hour.
Spring and autumn offer the most comfortable weather for exploring Charleston's historic district.