The distance from Pomona to San Francisco is about 650 kilometers. Driving via I-5 North is the most direct route, taking 6 to 8 hours depending on traffic. Alternatively, you can fly from nearby airports. San Francisco is famous for its iconic landmarks, hills, and culture. This is a very popular route.
Total Distance: Driving distance 650 km, straight-line air distance 600 km.
I-5 can be very congested during peak hours.
Anytime, but avoid peak holiday weekends.