The drive from Prairieville to Tampa is 750 miles and takes about 11 hours. You will head east on I-10 to I-75 South. This is a straightforward drive through the Florida panhandle and down the peninsula. Expect heavy traffic as you approach the Tampa metropolitan area.
Total Distance: 1,200 km driving distance; 1,050 km straight-line air distance.
Plan for a stopover in northern Florida to break up the drive.
Spring and fall offer the most comfortable temperatures.