The drive from Reno to Jackson takes you east through Nevada, Utah, Colorado, and into Mississippi. You will primarily use I-80 and I-40, covering 3,000 km in about 30 hours. This is a long-distance drive that requires careful planning for overnight stops.
Total Distance: 3,000 km driving, 2,600 km air distance.
Plan for multiple overnight stops.
Spring or Autumn for the best weather.