The drive from Reno to Oklahoma City takes you east through Nevada, Utah, Colorado, and into Oklahoma. You will primarily use I-80 and I-40, covering 2,200 km in about 22 hours. This is a long-distance drive that requires careful planning for overnight stops.
Total Distance: 2,200 km driving, 1,900 km air distance.
Plan for multiple overnight stops.
Spring or Autumn for the best weather.