The journey from Rochester to Des Moines covers about 550 miles. Driving is the most practical choice, taking about 8 hours via I-94 and I-80. This route takes you through the heart of the Midwest. It is a straightforward drive that is perfect for a weekend getaway.
Total Distance: 900 km driving, 750 km air distance.
Stop in Chicago for a break and a meal.
April to June or September to October for the most comfortable weather.