The drive from Sewanee to Durham takes you east through North Carolina. You will take I-24 East to I-40 East. The total distance is approximately 440 miles. Expect a drive time of about 7 hours. This route is well-traveled and straightforward.
Total Distance: 710 km driving distance, 570 km air distance.
Traffic in Knoxville and Durham can be heavy.
Spring for the beautiful city parks.