The drive from Sewanee to Myrtle Beach is approximately 520 miles. You will take I-24 to I-26, then transition to local highways to reach the coast. The trip takes about 8.5 hours. You will pass through Columbia, SC on your way. This is a very popular vacation route for families.
Total Distance: 835 km driving distance; 680 km straight-line air distance.
Expect heavy traffic on SC-501 as you approach the coast.
May or September for warm weather and fewer crowds.