How long is the drive?

The drive takes about 3.5 hours depending on traffic.

There is no direct passenger rail service between Shelbyville and Knoxville.

What is the best route?

Taking I-75 South is the most direct and efficient path.

There are no major tolls on this route.

You would need to drive to Louisville or Lexington to catch a flight to Knoxville.

Shelbyville

Knoxville

Driving

Shelbyville to Knoxville

Updated: 29 May 2026

The drive from Shelbyville to Knoxville is approximately 200 miles, primarily using I-75 South. You will travel through the scenic Appalachian foothills. The journey takes about 3.5 hours. Knoxville is a gateway to the Great Smoky Mountains and home to the University of Tennessee. This route is popular for those heading toward the mountains for vacation.

Total Distance: 320 km driving distance; 280 km straight-line air distance.

Fastest Way

Driving via I-75 South is the fastest route, taking about 3.5 hours.

Cheapest Way

Driving is the most economical and convenient way to reach Knoxville.

Compare Shelbyville to Knoxville Routes

Driving

Direct

Duration

3.5 hours

Avg Price

$40-$55 in fuel

Operator

Personal Vehicle

Route

I-64 East to I-75 South through Lexington.

Be prepared for winding roads and elevation changes as you approach Knoxville.

Travel Tips

Traffic
Traffic can be heavy near the I-75/I-40 interchange; plan accordingly.
Parking
Use city-managed garages in downtown Knoxville for easy access to attractions.
Dining
Try local Southern cuisine at restaurants in the Old City district.
Weather
Mountain weather can be unpredictable; pack a light jacket even in spring.
Navigation
Knoxville's hilly terrain can make GPS signals spotty; download offline maps.

Safety Tips

Driving
Watch for steep grades and sharp curves on I-75 through the mountains.
Personal Safety
Stay in well-lit areas when exploring the Old City at night.
Emergency
Keep your vehicle's emergency kit stocked for mountain driving conditions.
Vehicle Security
Always lock your car and remove valuables when parking in public lots.