The drive from Shepherdsville to Las Vegas is approximately 2000 miles, primarily using I-70 West and I-15 South. You will travel through the Midwest, the Rocky Mountains, and the desert Southwest. The drive typically takes 30 hours. This is a very long interstate route.
Total Distance: 3200 km driving distance; 2600 km straight-line air distance.
The drive through the mountains and desert is very scenic but long.
Spring or Autumn for the best weather in Las Vegas.