The drive from Shepherdsville to San Diego is approximately 2200 miles, primarily using I-65 South, I-40 West, and I-15 South. You will travel through the Midwest, the Great Plains, and the desert Southwest before reaching the Pacific Coast. The drive typically takes 33 hours. This is a very long interstate route.
Total Distance: 3540 km driving distance; 2900 km straight-line air distance.
The traffic in San Diego is extremely heavy.
Spring or Autumn for the best weather in San Diego.