How long is the drive?

The drive takes about 10 hours.

What is the best time to leave?

Early morning to avoid rush hour in Kansas City.

Yes, it follows major interstate highways.

Yes, but flights usually require a connection.

Sioux Falls

St. Louis

Driving

Sioux Falls to St. Louis

Updated: 28 May 2026

The journey from Sioux Falls to St. Louis covers approximately 650 miles. You will head south on I-29 to Kansas City, then transition to I-70 East. This is a long-haul drive that typically takes 10 hours. You will pass through major hubs like Omaha and Kansas City. Plan for multiple stops to ensure a safe and comfortable trip.

Total Distance: 1,050 km driving, 880 km air distance.

Fastest Way

Driving via I-29 and I-70 is the fastest method at 10 hours.

Cheapest Way

Driving is the most affordable way to reach St. Louis.

Compare Sioux Falls to St. Louis Routes

Driving

Direct

Duration

10 hours

Avg Price

$100-$150 in fuel

Operator

Personal Vehicle

Route

I-29 South to I-70 East.

Break the trip into two days if you prefer a relaxed pace.

Travel Tips

Planning
Use a GPS app to monitor traffic delays near Kansas City.
Hydration
Keep plenty of water in the car for the long drive.
Snacks
Pack healthy snacks to avoid relying on fast food.
Music
Download playlists or podcasts for the long stretches of highway.
Check-in
Book your hotel in St. Louis in advance to secure better rates.

Safety Tips

Night Driving
Avoid driving late at night to reduce the risk of fatigue-related accidents.
Vehicle Check
Check your oil and coolant levels before departing.
Weather
Monitor local news for severe weather alerts in the Midwest.
Communication
Share your itinerary with a friend or family member.