The trip from Sioux Falls to Des Moines covers roughly 280 miles. You will travel east on I-90 before merging onto I-35 South near Albert Lea. This route takes you through the heart of the Midwest agricultural belt. The drive is straightforward and typically takes 4 hours. It is a popular route for business and weekend travel.
Total Distance: 450 km driving, 380 km air distance.
Stop in Albert Lea for a quick lunch break.
Late spring or early autumn for comfortable driving conditions.