The drive from St. Joseph to Rochester is a 130-mile journey that takes approximately 2.5 hours. You will typically head east and south through the Twin Cities area. This is a common route for those traveling to the Mayo Clinic.
Total Distance: 210 km driving distance, 190 km straight-line air distance.
Traffic in the Twin Cities can be heavy; avoid rush hours.
Any time of year, but be prepared for winter snow.