Is there a bus to Durham?

Greyhound offers service to Durham from major hubs.

How long is the drive?

Approximately 6 hours and 15 minutes.

What is the best route?

I-75 South to I-40 East is the standard route.

Yes, it is a standard interstate drive.

Stearns

Durham

Driving

Stearns to Durham

Updated: 28 May 2026

The drive from Stearns to Durham is approximately 390 miles. You will head south on US-27 to I-75, then transition to I-40 East. This route typically takes 6 hours and 15 minutes. You will travel through the beautiful mountains of East Tennessee and Western North Carolina before reaching the Piedmont region. It is a scenic and relatively easy drive.

Total Distance: 630 km driving distance; 510 km straight-line air distance.

Fastest Way

Driving via I-75 and I-40 is the fastest, taking 6.25 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective method.

Compare Stearns to Durham Routes

Driving

Direct

Duration

6 hours 15 mins

Avg Price

$70-$95 in fuel

Operator

Personal Vehicle

Route

US-27 S to I-75 S, then I-40 E to Durham.

Durham traffic can be heavy; plan your arrival outside of rush hour.

Travel Tips

Traffic
Durham traffic can be heavy; use GPS to find real-time bypasses.
Dining
Try some local Southern comfort food in the downtown area.
Parking
Downtown Durham has plenty of parking options.
Navigation
Use GPS to navigate the city's road network.
Rest Stops
There are many rest areas along I-40 in North Carolina.

Safety Tips

Speed Limits
North Carolina state troopers are active on I-40; keep to the speed limit.
Weather
Be aware of potential thunderstorms in the summer.
Vehicle Safety
Check your brakes before the trip.
Emergency
Keep a first aid kit in your vehicle.