Is there a bus to Winston-Salem?

Greyhound offers service to Winston-Salem from major hubs.

What is the best route?

I-75 South to I-40 East is the standard route.

Yes, it is a standard interstate drive.

Stearns

Winston-Salem

Driving

Stearns to Winston-Salem

Updated: 28 May 2026

The drive from Stearns to Winston-Salem is approximately 310 miles. You will head south on US-27 to I-75, then transition to I-40 East. This route typically takes 5 hours. You will travel through the beautiful mountains of East Tennessee and Western North Carolina before reaching the Piedmont region. It is a scenic and relatively easy drive.

Total Distance: 500 km driving distance; 410 km straight-line air distance.

Fastest Way

Driving via I-75 and I-40 is the fastest, taking 5 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective method.

Compare Stearns to Winston-Salem Routes

Driving

Direct

Duration

5 hours

Avg Price

$55-$80 in fuel

Operator

Personal Vehicle

Route

US-27 S to I-75 S, then I-40 E to Winston-Salem.

Winston-Salem traffic can be heavy; plan your arrival outside of rush hour.

Travel Tips

Traffic
Winston-Salem traffic can be heavy; use GPS to find real-time bypasses.
Dining
Try some local Southern comfort food in the downtown area.
Parking
Downtown Winston-Salem has plenty of parking options.
Navigation
Use GPS to navigate the city's road network.
Rest Stops
There are many rest areas along I-40 in North Carolina.

Safety Tips

Speed Limits
North Carolina state troopers are active on I-40; keep to the speed limit.
Weather
Be aware of potential thunderstorms in the summer.
Vehicle Safety
Check your brakes before the trip.
Emergency
Keep a first aid kit in your vehicle.