The drive from Tupelo to Savannah covers about 800 kilometers and takes roughly 8.5 hours. You will head east on I-22, pass through Birmingham, and eventually take I-16 East across Georgia to reach the coast. This route is a classic Southern road trip, taking you through diverse landscapes from the hills of Mississippi to the low country of Georgia. It is a manageable drive for a single day.
Total Distance: 800 km driving distance; 680 km straight-line air distance.
Stop in Macon, Georgia, for a mid-trip break and lunch.
Spring, when the azaleas are in bloom, or Autumn for mild temperatures.