The drive from Tyler to San Antonio is approximately 300 miles and takes about 5 to 6 hours. The most direct route is via US-287 and I-35 South. San Antonio is a historic city known for the Alamo, the River Walk, and its rich cultural heritage. Plan your arrival to avoid the heavy traffic on I-35.
Total Distance: Driving distance 480 km; straight-line air distance 420 km.
I-35 is a major highway; expect heavy traffic near San Antonio.
Spring or Autumn for pleasant weather.