Is there a bus to Des Moines?

Yes, Jefferson Lines provides bus service to Des Moines from major hubs.

How long is the drive?

The drive is approximately 5 hours.

What is the best route?

US-61 North to US-218 North is the most direct path.

Flights to Des Moines (DSM) from St. Louis are usually connecting flights.

Is Des Moines worth visiting?

Yes, it is known for its vibrant arts scene and friendly atmosphere.

Wentzville

Des Moines

Driving

Wentzville to Des Moines

Updated: 28 May 2026

The drive from Wentzville to Des Moines covers roughly 330 miles, taking you north through the scenic Mississippi River valley. You will primarily use US-61 North and US-218 North, passing through Hannibal and Keokuk. This route avoids the heavy traffic of major interstates for much of the journey. Expect a travel time of approximately 5 hours. It is a pleasant drive through the heart of the American corn belt.

Total Distance: 531 km driving distance; 480 km straight-line air distance.

Fastest Way

Driving via US-61 and US-218 is the fastest route, taking 5 hours.

Cheapest Way

Driving your own vehicle is the most affordable option at roughly $45 in fuel.

Compare Wentzville to Des Moines Routes

Driving

Direct

Duration

5 hours

Avg Price

$40-$65

Operator

Personal Vehicle

Route

US-61 N to US-218 N through Hannibal and Iowa City.

Watch your speed in small towns along US-61, as limits drop quickly.

Travel Tips

Speed Traps
Be very careful with speed limits in small towns along the US-61 corridor.
Scenic Stops
Hannibal, Missouri, is a great place to stop and explore the Mark Twain history.
Road Conditions
Check the Iowa 511 website for construction updates on US-218.
Dining
Iowa City is a perfect midpoint for a lunch break with many diverse food options.
Parking
Downtown Des Moines has ample parking garages that are reasonably priced on weekends.

Safety Tips

Rural Roads
Be cautious of slow-moving agricultural machinery during harvest seasons.
Night Driving
Avoid driving on rural two-lane highways at night due to limited lighting and wildlife.
Weather
Iowa can experience sudden thunderstorms; keep your headlights on during heavy rain.
Emergency Supplies
Carry a portable charger and extra water, as some stretches of US-218 are remote.