How long is the drive from Ames to St. Louis?

The drive typically takes 6 hours.

Is there a train from Ames to St. Louis?

No, there is no direct passenger rail service between these two cities.

What is the best way to travel to St. Louis from Ames?

Driving is the most convenient and direct method.

Are there tolls on the way to St. Louis?

No, there are no major toll roads on this specific route.

Is St. Louis a good weekend trip from Ames?

Yes, it offers a wide range of cultural and historical attractions.

Ames

St. Louis

Driving

Ames to St. Louis

Updated: 28 May 2026

The journey from Ames to St. Louis is approximately 400 miles. You will typically take I-35 South to I-80 East, then connect to I-55 South or I-70 East depending on your specific destination in the city. The drive takes about 6 hours. This route takes you through the heart of the Midwest, passing through Des Moines and crossing into Missouri. It is a popular route for those visiting the Gateway Arch.

Total Distance: 645 km driving distance; 550 km straight-line air distance.

Fastest Way

Driving via the interstate system is the fastest method, taking 6 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective way to reach St. Louis.

Compare Ames to St. Louis Routes

Driving

Direct

Duration

6 hours

Avg Price

$70-$100 in fuel

Operator

Personal Vehicle

Route

I-35 South to I-80 East to I-55 South.

Ensure your vehicle is in good condition for this longer drive.

Travel Tips

Navigation
Use GPS to navigate the complex highway system in St. Louis.
Rest Stops
Plan for stops in major cities like Des Moines or along the I-55 corridor.
Traffic
Avoid the downtown St. Louis area during morning and evening rush hours.
Parking
Use parking apps to find secure garages near the Gateway Arch and downtown attractions.
Planning
Check for road construction on I-55, as it is a major artery.

Safety Tips

Speeding
Be aware of speed enforcement on the interstate highways.
Fatigue
Take regular breaks to stay alert during the 6-hour drive.
Emergency
Keep a basic emergency kit in your car, including water and a first-aid kit.
Visibility
Use headlights during rain or low-light conditions.