Is there a bus to Birmingham?

Yes, Greyhound offers service, but it requires multiple transfers.

How long is the flight?

Total travel time including layovers is usually 5 to 6 hours.

What is the best time to visit?

Spring and fall offer the most comfortable weather.

Amtrak does not serve a direct route from Anderson to Birmingham.

Yes, it is a major, well-patrolled interstate highway.

Anderson

Birmingham

Flight Driving

Anderson to Birmingham

Updated: 28 May 2026

Traveling from Anderson to Birmingham is a straightforward 700-kilometer drive primarily using I-65 South. You will traverse through Louisville, Kentucky, and Nashville, Tennessee, before entering Alabama. The route is well-maintained and offers numerous rest stops. For those preferring air travel, flights depart from Indianapolis International Airport to Birmingham-Shuttlesworth International Airport.

Total Distance: 700 km driving, 650 km air distance.

Fastest Way

Flight is faster, but requires airport transit time.

Cheapest Way

Driving is the most economical choice for individuals or groups.

Compare Anderson to Birmingham Routes

	Flight Connecting	Driving Direct
Duration	5 hours	7 hours
Avg Price	$300-$500	$75-$110 in fuel
Operator	Delta Air Lines	Personal Vehicle
Route	IND to BHM via ATL.	I-69 S to I-465 S, then I-65 S all the way to Birmingham.
Tip	Connecting through Atlanta is the most frequent option.	The I-65 corridor is prone to heavy truck traffic.

Travel Tips

Route Planning
Use a GPS app to monitor real-time traffic delays in Louisville.
Rest Stops
The Buc-ee's in Athens, Alabama, is a popular and clean stop near the end of the route.
Tolls
There are no tolls on the I-65 route from Anderson to Birmingham.
Packing
Bring layers, as Alabama weather can change quickly in the spring.
Car Prep
Check your tire pressure before leaving, as highway speeds are sustained for hours.

Safety Tips

Speed Limits
Strictly observe speed limits in small towns along I-65 in Alabama.
Fatigue
Switch drivers every 3 hours to maintain alertness on the long interstate stretch.
Emergency
Keep a physical map in the glove box in case of GPS failure.
Parking
Always park in well-lit, attended lots when visiting downtown Birmingham.