Bus
Driving
Biloxi to Birmingham
Updated: 28 May 2026
The trip from Biloxi to Birmingham is a 300-mile drive north through Mississippi and Alabama. Taking US-49 North to I-59 North is the most direct route, taking about 4.5 hours. Birmingham is a historic city with a rich industrial heritage and a growing cultural scene.
Total Distance: 480 km driving, 420 km air distance.
Fastest Way
Driving via US-49 and I-59 is the fastest way to reach Birmingham.
Cheapest Way
Driving is the most cost-effective for individuals.
Compare Biloxi to Birmingham Routes
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Direct
|
Direct
|
|
|---|---|---|
| Duration | 6 hours | 4 hours 30 mins |
| Avg Price | $50-$80 | $45-$65 in fuel |
| Operator | Greyhound | Personal Vehicle |
| Route | Biloxi Transit Center to Birmingham Greyhound Station. | US-49 N, I-59 N. |
| Tip | Book tickets in advance for better pricing. | The route is straightforward; be mindful of speed limits. |
Travel Tips
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Speed LimitsBe careful of speed traps in small towns along the route.
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ParkingDowntown Birmingham has plenty of parking options.
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WalkingSome areas of Birmingham are walkable, but a car is recommended.
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WeatherAlabama can be hot in the summer; stay hydrated.
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EventsCheck for local festivals and events in Birmingham.
Safety Tips
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Stay AlertBe aware of your surroundings in downtown areas at night.
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NavigationUse GPS to navigate the city streets.
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Vehicle SafetyLock your car and keep valuables out of sight.
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EmergencyKnow the location of the nearest hospital.
People Also Ask
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How long is the drive?It is about 4.5 hours.
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Is there a train?No, there is no direct passenger rail service between Biloxi and Birmingham.
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What is the best way to travel?Driving is the most convenient and flexible option.
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Are there tolls?No, there are no tolls on the route between Biloxi and Birmingham.
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Is it safe to drive at night?Yes, the highways are well-lit and heavily traveled.
Quick Info
- From Biloxi, Mississippi, United States
- To Birmingham, Alabama, United States
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Modes
Best Time to Travel
Spring or Autumn for pleasant weather.
Things to Do in Birmingham
1
Birmingham Civil Rights Institute
A powerful museum detailing the history of the Civil Rights Movement in Birmingham.
2
Barber Vintage Motorsports Museum
A world-class museum featuring a massive collection of vintage motorcycles.
3
Railroad Park
A beautiful urban park in the heart of downtown Birmingham.
4
Sloss Furnaces National Historic Landmark
Explore the history of the city's industrial past.
Tags
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