Greenwood
Greenwood
Biloxi
Biloxi
Driving

Greenwood to Biloxi

Updated: 28 May 2026

The drive from Greenwood to Biloxi is a 250-mile journey across the state of Mississippi. You will primarily use US-49 S, passing through Jackson. The trip takes about 4 hours of driving time. Biloxi is famous for its casinos, beaches, and seafood. Prepare for a scenic drive through the heart of the Magnolia State.

Total Distance: 402 km driving, 350 km air distance.
Fastest Way
Driving is the most practical method for this route.
Cheapest Way
Driving is the most economical way to reach Biloxi.
Compare Greenwood to Biloxi Routes
Driving
Direct
Duration
4 hours
Avg Price
$40-$60 in fuel
Operator
Personal Vehicle
Route
US-49 S.

Stop in Jackson for a quick break.

Travel Tips
  • Parking
    Use the parking garages at the casinos.
  • Hydration
    Carry plenty of water for the humid climate.
  • Navigation
    Use GPS to navigate the coastal roads.
  • Dining
    Try the local seafood in Biloxi.
  • Weather
    Be prepared for humidity in the summer.
Safety Tips
  • Fatigue
    Take a break in Jackson.
  • Vehicle Prep
    Check your tires and brakes before the trip.
  • Emergency Kit
    Carry extra water and food.
  • Road Conditions
    Check for construction on US-49.
People Also Ask
  • Is it a long drive?
    No, it is only about 4 hours.
  • Are there tolls?
    No, there are no tolls on this route.
  • What is the best route?
    US-49 S is the most direct path.
  • Is Biloxi safe?
    It is generally safe, but standard urban precautions apply.
  • Can I fly?
    No, there are no practical flights for this short distance.
Quick Info
  • From Greenwood, Mississippi, United States
  • To Biloxi, Mississippi, United States
  • Modes
Best Time to Travel

Spring or Autumn for the best weather.

Things to Do in Biloxi
1
Biloxi Beach
Enjoy the beautiful sandy beaches and the Gulf of Mexico.
2
Beau Rivage Resort & Casino
Experience the luxury and entertainment of this famous casino.
3
Biloxi Lighthouse
Visit the historic lighthouse that has become a symbol of the city.
4
Maritime and Seafood Industry Museum
Learn about the rich maritime history of the region.
Tags
Greenwood to Biloxi driving to Biloxi MS to MS road trip Greenwood to MS coast best route to Biloxi Mississippi travel Biloxi travel guide traveling south from Greenwood
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