Is there a train to Little Rock?

Amtrak's Texas Eagle stops in Little Rock, but there is no rail service from Cape Girardeau.

How long is the drive?

The drive takes about 3 hours and 45 minutes.

What is the best route?

I-55 South to I-40 West is the standard and most efficient route.

There are no direct commercial flights between these two cities.

Cape Girardeau

Little Rock

Driving

Cape Girardeau to Little Rock

Updated: 28 May 2026

The trip from Cape Girardeau to Little Rock covers roughly 230 miles. You will head south on I-55 toward Memphis, then transition to I-40 West to reach Little Rock. This route takes you through the flat agricultural lands of the Mississippi Delta. The total driving time is approximately 3.5 to 4 hours. It is a straightforward drive that connects the bootheel of Missouri to the capital of Arkansas.

Total Distance: 370 km driving distance, 315 km straight-line air distance.

Fastest Way

Driving via I-55 and I-40 is the fastest and most direct route.

Cheapest Way

Driving your own car is the most economical way to travel this distance.

Compare Cape Girardeau to Little Rock Routes

Driving

Direct

Duration

3 hours 45 mins

Avg Price

$40-$55 in fuel

Operator

Personal Vehicle

Route

I-55 South to Memphis, then I-40 West to Little Rock.

Be prepared for heavy truck traffic on the I-40 corridor.

Travel Tips

Memphis Traffic
Try to pass through Memphis during off-peak hours to avoid bridge and interstate congestion.
Rest Stops
There are numerous rest areas along I-40 between Memphis and Little Rock.
Dining
Stop in West Memphis for a variety of quick-service food options.
Navigation
Use a GPS app to monitor real-time traffic accidents on I-40.
Hydration
Keep water in your car, as Arkansas summers can be extremely hot.

Safety Tips

Truck Traffic
Maintain a safe following distance from semi-trucks on I-40.
Weather
Be aware of potential severe weather alerts in the Mississippi River valley.
Road Hazards
Watch for debris on the highway, especially after heavy rain.
Visibility
Use your headlights during rainstorms, which are common in this region.