The drive from Cape Girardeau to Memphis is a 280-kilometer journey. The most practical mode is driving via I-55 S, which takes approximately 3 hours. You will cross from Missouri into Arkansas and then into Tennessee. This route is a major corridor for travel between the two cities.
Total Distance: 280 km driving distance; 250 km straight-line air distance.
Traffic can be heavy entering Memphis.
Spring or autumn for pleasant weather.