Driving
Cape Girardeau to Memphis
Updated: 28 May 2026
The drive from Cape Girardeau to Memphis is a 280-kilometer journey. The most practical mode is driving via I-55 S, which takes approximately 3 hours. You will cross from Missouri into Arkansas and then into Tennessee. This route is a major corridor for travel between the two cities.
Total Distance: 280 km driving distance; 250 km straight-line air distance.
Fastest Way
Driving is the fastest, taking 3 hours.
Cheapest Way
Driving is the most cost-effective and practical way to reach Memphis.
Compare Cape Girardeau to Memphis Routes
Driving
Direct
Duration
3 hours
Avg Price
$40-$50 in fuel
Operator
Personal Vehicle
Route
I-55 S directly to Memphis.
Traffic can be heavy entering Memphis.
Travel Tips
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TrafficAvoid Memphis rush hour to save time.
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ParkingUse parking garages in downtown Memphis.
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GPSUse real-time traffic apps for the best route.
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RestTake a break in Blytheville if needed.
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SnacksKeep water in the car for the drive.
Safety Tips
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SpeedFollow speed limits on I-55.
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WeatherCheck for rain or storm warnings.
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VehicleEnsure your car is in good condition.
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AlertnessStay focused on the highway traffic.
People Also Ask
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Is there a train?No, there is no direct train service.
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How long is the drive?Approximately 3 hours.
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Are there tolls?No, this route is toll-free.
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What is the best route?I-55 S is the most direct.
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Is it a safe drive?Yes, it is a well-traveled highway.
Quick Info
- From Cape Girardeau, Missouri, United States
- To Memphis, Tennessee, United States
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Modes
Best Time to Travel
Spring or autumn for pleasant weather.
Things to Do in Memphis
1
Graceland
Visit the home of Elvis Presley.
2
Beale Street
Experience the famous blues music and nightlife.
3
National Civil Rights Museum
Learn about the history of the civil rights movement.
4
Sun Studio
Take a tour of the legendary recording studio.
Tags
Cape Girardeau to Memphis drive
driving to Memphis from Cape Girardeau
Missouri to Tennessee road trip
Cape Girardeau transport
Memphis travel guide
I-55 route
best way to Memphis
Southern travel
