Is there a train to Louisville?

There is no direct passenger rail service to Louisville from Cape Girardeau.

How long is the drive?

The drive takes about 4 hours and 30 minutes.

Some bridges in the Louisville area may have tolls.

What is the best route?

I-64 East is the standard and most efficient route.

There are no direct commercial flights between these two cities.

Cape Girardeau

Louisville

Driving

Cape Girardeau to Louisville

Updated: 28 May 2026

The journey from Cape Girardeau to Louisville covers approximately 280 miles. You will head east on IL-146 and I-64 through southern Illinois and Indiana to reach Louisville. This route takes you across the scenic landscape of the Ohio River valley. The total driving time is approximately 4.5 hours. It is a direct and efficient route connecting the two states.

Total Distance: 450 km driving distance, 380 km straight-line air distance.

Fastest Way

Driving via I-64 is the fastest and most direct route.

Cheapest Way

Driving your own vehicle is the most cost-effective way to make this trip.

Compare Cape Girardeau to Louisville Routes

Driving

Direct

Duration

4 hours 30 mins

Avg Price

$50-$70 in fuel

Operator

Personal Vehicle

Route

IL-146 East to I-64 East to Louisville.

Be prepared for potential traffic near the Louisville bridge crossings.

Travel Tips

Bridge Traffic
Expect heavy traffic on the bridges crossing the Ohio River during rush hour.
Rest Stops
There are several rest areas along I-64 in Illinois and Indiana.
Dining
Try the local hot brown sandwich at a restaurant in downtown Louisville.
Navigation
Use a GPS to navigate the city streets of Louisville.
Fuel
Gas prices are often lower in rural areas than in the city.