Driving
De Pere to La Crosse
Updated: 31 May 2026
The drive from De Pere to La Crosse is approximately 180 miles southwest. This journey typically takes 3 hours, passing through the scenic landscapes of central and western Wisconsin. La Crosse is located on the Mississippi River and is known for its historic downtown, outdoor recreation, and the University of Wisconsin-La Crosse. It is a popular destination for travelers in the region.
Total Distance: 290 km driving distance; 250 km straight-line air distance.
Fastest Way
Driving via WI-29 and I-90 is the fastest, taking about 3 hours.
Cheapest Way
Driving your own vehicle is the most practical and cost-effective method.
Compare De Pere to La Crosse Routes
Driving
Direct
Duration
3 hours
Avg Price
$30 - $45 in fuel
Operator
Personal Vehicle
Route
WI-29 W to I-90 W.
I-90 is a major interstate and provides a direct route to La Crosse.
Travel Tips
-
TrafficTraffic is generally light, but be aware of construction on I-90.
-
ParkingDowntown La Crosse has ample parking available.
-
NavigationUse a GPS to navigate the city's layout.
-
DiningExplore the local restaurants in downtown La Crosse.
-
EventsCheck the La Crosse event calendar for festivals and concerts.
Safety Tips
-
Speed LimitsFollow speed limits on I-90, especially in construction zones.
-
WeatherBe prepared for snow during the winter months.
-
VisibilityUse headlights during rain or snow to stay visible.
-
EmergencyKeep a roadside emergency kit in your vehicle.
People Also Ask
-
How long is the drive?It takes about 3 hours.
-
Is there a train?No, there is no direct passenger rail service.
-
What is the best highway?WI-29 W to I-90 W is the primary route.
-
Is La Crosse far from De Pere?It is about 180 miles away.
-
Are there buses?There is no direct intercity bus service.
Quick Info
- From De Pere, Wisconsin, United States
- To La Crosse, Wisconsin, United States
-
Modes
Best Time to Travel
Late spring or early autumn for pleasant weather on the river.
Things to Do in La Crosse
1
Grandad Bluff
Enjoy breathtaking panoramic views of the Mississippi River valley.
2
Riverside Park
Stroll along the Mississippi River and enjoy the scenic views.
3
Hixon Forest
Explore miles of hiking and biking trails in this beautiful forest.
4
Dahl Auto Museum
Learn about the history of the automobile in this unique museum.
Tags
De Pere to La Crosse
drive to La Crosse
WI-29/I-90 travel
Wisconsin travel
La Crosse transit
De Pere commute
Mississippi River
Wisconsin road trip
