Driving
Rhinelander to La Crosse
Updated: 28 May 2026
The journey from Rhinelander to La Crosse is a 300-kilometer drive heading southwest. You will take US-51 and WI-21 to reach the city of La Crosse on the Mississippi River. The drive typically takes about 3.5 hours. La Crosse is known for its stunning river bluffs, its historic downtown, and its vibrant university life. This is a popular route for those traveling to Western Wisconsin.
Total Distance: 300 km driving, 270 km air distance.
Fastest Way
Driving is the fastest method, taking 3.5 hours.
Cheapest Way
Driving is the most economical choice, costing about 50 dollars in fuel.
Compare Rhinelander to La Crosse Routes
Driving
Direct
Duration
3 hours 30 mins
Avg Price
45-60 USD
Operator
Personal Vehicle
Route
US-51 South to WI-21 West.
The route is very scenic as you approach the Mississippi River.
Travel Tips
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NavigationWI-21 is a reliable route, but watch for speed changes in small towns.
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ParkingDowntown La Crosse has plenty of parking, and most of it is free.
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DiningTry the local restaurants near the riverfront.
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EventsCheck the local events calendar for river festivals.
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WeatherMississippi River valley weather can change quickly; check the forecast before leaving.
Safety Tips
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WildlifeBe alert for deer on rural stretches of the route.
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Winter DrivingCarry an emergency kit; the roads can be slippery in winter.
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Road ConditionsCheck Wisconsin 511 for any construction or weather alerts.
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EmergencyLa Crosse has excellent medical facilities if needed.
People Also Ask
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Is there a bus to La Crosse?There is no direct intercity bus service from Rhinelander.
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How long is the drive?The drive takes about 3.5 hours.
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Is it a scenic route?Yes, the route passes through beautiful Wisconsin farmland and river bluffs.
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Are there trains?No, there is no passenger rail service between these cities.
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What is the best route?US-51 to WI-21 is the most direct path.
Quick Info
- From Rhinelander, Wisconsin, United States
- To La Crosse, Wisconsin, United States
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Modes
Best Time to Travel
Summer for river activities or autumn for the spectacular fall colors on the bluffs.
Things to Do in La Crosse
1
Grandad Bluff
Drive to the top of this bluff for a panoramic view of the city and the Mississippi River. It is a must-visit.
2
Riverside Park
Walk along the riverfront, visit the gardens, and enjoy the views of the Mississippi River.
3
Historic Downtown
Explore the shops, restaurants, and historic buildings in the heart of La Crosse.
4
Hixon Forest
Hike the trails in this beautiful forest area for great views and nature experiences.
Tags
Rhinelander to La Crosse
drive to La Crosse
WI-21 route
Wisconsin travel
Rhinelander transport
La Crosse commute
fastest way to La Crosse
road trip
