Driving
Hattiesburg to Knoxville
Updated: 28 May 2026
The drive from Hattiesburg to Knoxville takes about 7 hours and covers 650 kilometers. You will travel north on I-59 to Chattanooga, then north on I-75 into Knoxville. This route takes you through the heart of Mississippi, Alabama, and into Tennessee. It is a straightforward drive on major interstate highways. Knoxville is known for its riverfront, museums, and cultural attractions.
Total Distance: 650 km driving distance; 580 km straight-line air distance.
Fastest Way
Driving is the fastest method, taking 7 hours.
Cheapest Way
Driving your own vehicle is the most practical and cheapest way to travel.
Compare Hattiesburg to Knoxville Routes
Driving
Direct
Duration
7 hours
Avg Price
$80-$100 in fuel
Operator
Personal Vehicle
Route
I-59 N to I-75 N.
Traffic in Birmingham, Chattanooga, and Knoxville can be heavy; plan accordingly.
Travel Tips
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Route ChoiceI-75 is a major interstate; expect heavy truck traffic.
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DiningKnoxville has a variety of local restaurants serving Southern cuisine.
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PlanningCheck for local events before you travel.
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NavigationUse a GPS to navigate the highway transitions.
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ParkingParking is generally easy to find in Knoxville.
Safety Tips
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Speed LimitsBe aware of speed limit changes on I-75.
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WeatherCheck for heavy rain alerts during the summer.
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FatigueTake breaks to stay alert on the highway.
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EmergencyKeep a basic emergency kit in your car.
People Also Ask
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Is there a train?There is no passenger train service to Knoxville.
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How long is the drive?The drive takes approximately 7 hours.
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What is the best route?I-59 to I-75 is the most efficient route.
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Are there tolls?There are no tolls on this route.
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Is it a safe drive?Yes, it is a major interstate route.
Quick Info
- From Hattiesburg, Mississippi, United States
- To Knoxville, Tennessee, United States
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Modes
Best Time to Travel
Spring and Autumn are best for outdoor activities in Knoxville.
Things to Do in Knoxville
1
Market Square
A vibrant area with shops, restaurants, and cultural events.
2
World's Fair Park
Features the Sunsphere and beautiful gardens.
3
Ijams Nature Center
A great place for hiking and nature walks.
4
Downtown Knoxville
Features local shops, restaurants, and cultural attractions.
Tags
Hattiesburg to Knoxville drive
I-59 to I-75
travel Hattiesburg to Knoxville
Knoxville travel
driving time Hattiesburg to Knoxville
road trip
how to get to Knoxville
Knoxville tourism
