Is there a bus to Charleston?

No, there is no direct bus service from Highlands to Charleston.

No, there is no passenger rail service on this route.

Yes, it is a well-traveled and safe interstate route.

What is the best time to leave?

Early morning to avoid traffic in the city.

Highlands

Charleston

Driving

Highlands to Charleston

Updated: 28 May 2026

The journey from Highlands to Charleston covers 450 kilometers, moving from the mountains to the coast of South Carolina. You will take US-64 E to I-26 E, which leads directly to Charleston. The drive typically takes 5 hours. This route offers a dramatic transition from mountain scenery to the historic coastal city. It is a major corridor for travel in the state.

Total Distance: 450 km driving distance; 380 km straight-line air distance.

Fastest Way

Driving via I-26 E is the fastest route, taking 5 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective method at 65 dollars in fuel.

Compare Highlands to Charleston Routes

Driving

Direct

Duration

5 hours

Avg Price

60-70 dollars

Operator

Personal Vehicle

Route

US-64 E to I-26 E.

Stop in Columbia for a break.

Travel Tips

Traffic
Traffic can be heavy in Charleston; plan your arrival for off-peak hours.
Parking
Use the public parking garages in downtown Charleston.
Dining
Charleston has a world-class food scene; try the local seafood.
Navigation
Use a GPS to navigate the city's streets.
Fuel
Gas prices are generally lower in South Carolina than in North Carolina.