Traveling from the high elevation of Highlands to the coastal charm of Savannah covers roughly 600 kilometers. The most efficient route involves taking US-64 to I-26, then connecting to I-95 South. This journey takes approximately 6 hours and 30 minutes of pure driving time. You will experience a dramatic change in landscape from the Appalachian Mountains to the Atlantic lowlands. Driving is the only practical mode for this specific route.
Total Distance: 600 km driving distance; 480 km straight-line air distance.
Stop in Columbia for a mid-way break to stretch your legs.
Spring, when the azaleas are in bloom in Savannah and the mountain weather is mild.