The drive from Highlands to St. Louis covers approximately 950 kilometers. You will travel north through the mountains, eventually merging onto I-64 West. The journey takes about 10 hours. This route takes you through the heart of the Midwest. Driving is the only practical mode of transport for this trip.
Total Distance: 950 km driving distance; 800 km straight-line air distance.
This is a long drive; plan for an overnight stop if needed.
Spring or Fall, when the weather is mild and perfect for exploring the city.