The journey from Hilton Head Island to Baltimore covers approximately 600 miles. You will primarily use I-95 North to reach the city. The drive typically takes 9 hours. You will pass through major cities like Richmond and Washington, D.C. The route is well-serviced with gas stations and restaurants. It is a long but common route for those traveling to the Mid-Atlantic.
Total Distance: 965 km driving distance; 825 km straight-line air distance.
Traffic on I-95 in the Mid-Atlantic corridor is notoriously heavy; plan accordingly.
Spring and fall offer the best weather for exploring the city.