The journey from Hilton Head Island to Birmingham covers approximately 450 miles. You will primarily use I-26 and I-20 to reach the city. The drive typically takes 7 hours. You will pass through major cities like Columbia and Atlanta. The route is well-serviced with gas stations and restaurants. It is a long but common route for those traveling to the South.
Total Distance: 724 km driving distance; 625 km straight-line air distance.
Traffic around Atlanta can be heavy; plan accordingly.
Spring and fall offer the best weather for exploring the city.