The journey from Hilton Head Island to Houston covers approximately 1050 miles. You will primarily use I-10 to reach the city. The drive typically takes 16 hours. You will pass through major cities like Jacksonville, Mobile, and Baton Rouge. The route is well-serviced with gas stations and restaurants. It is a long but common route for those traveling to the Gulf Coast.
Total Distance: 1690 km driving distance; 1450 km straight-line air distance.
Traffic around Houston can be heavy; plan accordingly.
Spring and fall offer the best weather for exploring the city.