The drive from Hilton Head Island to Indianapolis covers approximately 1,150 kilometers. You will travel through South Carolina, North Carolina, Tennessee, Kentucky, and into Indiana. The most common route uses I-26, I-75, and I-65. Driving time is typically 11.5 hours depending on traffic. Personal vehicle is the most practical mode of transport.
Total Distance: 1,150 km driving distance; 950 km straight-line air distance.
Plan for a rest stop in Louisville to break up the long drive.
Spring or Fall for pleasant weather in the city.