The drive from Hilton Head Island to Kansas City covers approximately 1,600 kilometers. You will travel through South Carolina, North Carolina, Tennessee, Kentucky, Indiana, Illinois, and into Missouri. The most common route uses I-26 and I-70. Driving time is typically 16 hours depending on traffic. Personal vehicle is the most practical mode of transport.
Total Distance: 1,600 km driving distance; 1,400 km straight-line air distance.
Plan for a rest stop in St. Louis to break up the long drive.
Spring or Fall for pleasant weather in the city.