The journey from Hilton Head Island to Nashville covers approximately 550 miles. You will primarily use I-26 and I-40 to reach the city. The drive typically takes 8 hours and 30 minutes. You will pass through major cities like Columbia and Asheville. The route is well-serviced with gas stations and restaurants. It is a long but common route for those traveling to the South.
Total Distance: 885 km driving distance; 750 km straight-line air distance.
Traffic around Nashville can be heavy; plan accordingly.
Spring and fall offer the best weather for exploring the city.