Yes, but it requires a transfer in St. Louis.

How long is the drive?

It is approximately 6 hours via I-55 N.

It has areas with high crime; stick to the tourist-friendly downtown and lakefront areas.

What is the best way to travel?

Driving is faster, while the train is more relaxing.

Are there direct routes?

Driving is direct; the train requires a transfer.

Jefferson City

Chicago

Train Driving

Jefferson City to Chicago

Updated: 28 May 2026

The journey from Jefferson City to Chicago is a long but manageable trip across the Midwest. You can take the Amtrak train, which involves a transfer in St. Louis, or drive via I-55 N. The train ride takes about 8 to 9 hours, while driving takes approximately 6 hours. This route connects the state capital to the major metropolitan hub of Chicago.

Total Distance: Driving distance 600 km, straight-line air distance 520 km.

Fastest Way

Driving, typically taking 6 hours depending on traffic.

Cheapest Way

Amtrak train, starting at 60 dollars if booked in advance.

Compare Jefferson City to Chicago Routes

	Train Connecting	Driving Direct
Duration	9 hours	6 hours
Avg Price	60-120 USD	60-80 USD (fuel)
Operator	Amtrak	N/A
Route	Jefferson City to St. Louis to Chicago	I-55 N
Tip	The train is a relaxing way to travel, but requires a transfer in St. Louis.	Driving is the fastest way to reach Chicago, but be prepared for heavy traffic.

Travel Tips

Train Travel
Book your Amtrak tickets early to get the best prices.
Driving
Be prepared for heavy traffic when entering Chicago during rush hour.
Walking
Downtown Chicago is very walkable, and public transit is excellent.
Dining
Try the local deep-dish pizza and Chicago-style hot dogs.
Parking
Parking is expensive in Chicago; use public transit or parking garages.

Safety Tips

General Safety
Chicago has areas with high crime; stay in well-traveled tourist zones.
Night Safety
Avoid walking alone at night, especially in less populated areas.
Driving
Keep your car doors locked and do not leave valuables visible.
Emergency
Keep emergency numbers saved and stay aware of your surroundings.