The trip from Jefferson City to Springfield is a scenic drive through the heart of the Missouri Ozarks. You can take US-50 W to US-65 S, which connects the two cities in about 2 hours and 30 minutes. This route is popular for those looking to explore the natural beauty and outdoor activities of the Ozarks. There is no direct train service, so driving is the most practical option.
Total Distance: Driving distance 220 km, straight-line air distance 190 km.
The drive through the Ozarks is very scenic, especially in the fall.
April to June or September to October for mild weather and outdoor activities.